AfricArxiv Repository :: Browsing by Author "ST Communication"

Browsing by Author "ST Communication"

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Àwọn oníwádìí sọ pé fáírọ́ọ̀sì COVID-19 lè má tètè yírapadà, èyí tó jẹ́ kí ṣíṣe àjẹ́sára yá
(2023-10-02) ST Communication
Àjàkálẹ̀ àrùn COVID-19 ń lọ lọ́wọ́lọ́wọ́ láti ìgbà tó ti bẹ̀rẹ̀ ní ìparí osù Belu ọdún 2019 ní Wuhan, China. Lílo òye àti ṣiṣe àbójútó ìtànkálẹ̀ ìpilẹ̀-ara fáírọ́òsì náà, àwọn àbùdá agbègbè rẹ̀, àti ìdúróṣin rẹ̀ ṣe pàtàkì fún àti ṣe ìsàkóso ìtànkálẹ̀ àrùn náà àti fún ìdàgbàsókè àjẹsára káríayé tó bo gbogbo àwọn iṣan. Láti ìhà yìí, a ṣe àtúpalẹ̀ ìpìlẹ̀-ara 30,983 SARS-CoV-2 láti àwọn orílé-ède 79 tó wà ní oríṣiríṣi kọ́ńtínẹ́ẹ̀tì mẹ́fà tí a sì gbà láti 24 oṣù Ọpẹ́ ọdún 2019, títí dé 13 osù Èbìbí 2020, ní ìbámu pẹ̀lú àkójọ dátà ti GISAID. Àtúpalẹ̀ wa fi ààyè ìyàtọ̀ 3206 hàn, pẹ̀lú ìṣọ̀kan ìfọnká irúfẹ́ ìyípadà ní oríṣiríṣi agbègbè. Pẹ̀lú ìyàlẹ́nu, a ti ṣe àkíyèsí ìgbóhùnsáfẹ́fẹ́ tí ìyípadà lóòrẹ̀kóòrè; ìyípadà 169 péré (5.27%) ní ìtànkálẹ̀ ìpìlẹ̀-ara tí ó tóbi jù pẹ̀lú 1%. Bí ó tilẹ̀ jẹ́ pé, àwọ́n àmúkù mẹ́rìnlá tí kò bára jọ (>10%) ní a ti ṣèdámọ̀ ní àwọn ibi ọ̀tọ̀ọ̀tọ̀ ní ibi ìpìlẹ̀-ara; mẹ́jọ nínú ORF1ab (nínú nsp2, nsp3, àyè awọ, RdRp, ẹ́líkeèsì, ẹksonukílìs àti ẹndoribonukílíìsì), mẹ́ta nínú amúaradàgbà nukilioscásíìdì, àti ọ̀kà nínú purotéènì mẹ́ta:
Masu binciken sun ce ƙwayar cutar ta COVID-19 na iya sauyawa a hankali, ta sa ci gaban rigakafin cikin sauƙi
(2023-10-02) ST Communication
Annobar cutar COVID-19 tana ci gaba da taɓarɓarewa tun farkonta a ƙarshen watan Nuwamban na shekarar 2019 a birnin Wuhan na ƙasar Sin. Fahimtar da kuma sa-ido a kan yadda ƙwayar halittar ƙwayar cutar take faruwa, yanaye-yanayenta na wuri, da kwanciyar tsayuwarta yana da matuƙar muhimmanci, musamman wajen daƙile yaɗuwar cutar musamman ga samar da allurar rigakafi ta duniya da take rufe dukkan nau’o’in da suke yawo. Daga wannan ra’ayi, mun bincika cikakkun ilahirin ƙwayoyin gadon SARS-CoV-2 guda 30,983 daga ƙasashe 79 da ke cikin nahiyoyi shida kuma muka tattara daga 24 ga watan Disamba 2019, zuwa 13 ga Mayu 2020, bisa ga rumbun bayanan GISAID. Bincikenmu ya nuna kasancewar ɓangarorin rukunoni 3206, tare da rarraba iri ɗaya na sauyi a yankuna daban-daban. Abin sha’awa shi ne, an lura da ƙarancin maimaituwar sauyi; sauyi guda 169 kawai ne (kashi 5.27%) suka sami yaɗuwa fiye da kashi 1% na ilahirin ƙwayoyin gadon. Duk da haka, an gano sauye-sauye goma sha huɗu waɗanda ba a san su ba (> 10%) a wurare daban-daban tare da ilahirin ƙwayoyin gadon ƙwayar cutar; takwas a cikin ORF1ab polyprotein (a cikin nsp2, nsp3, yankin transmembrane, RdRp, helicase, exonuclease, da endoribonuclease), uku a cikin furotin nucleocapsid, kuma ɗaya a cikin kowane sinadaran guda uku: Spike, ORF3a, da kuma ORF8. Haka kuma, an gano sauye guda 36 da ba a san su ba a cikin yankin muhimmin ɓangaren ƙwayar cuta (RBD) na furotin mai kauri tare da ƙarancin yaɗuwa (<1%) a duk nau’o’in ƙwayoyin gadon, waɗanda huɗu ne kawai za su iya haɓaka ɗaurin SARS-CoV- 2 furotin mai kauri ga mai karɓar ACE2 na ɗan’adam. Waɗannan sakamakon tare da bambance-bambancen juyin ƙwayoyin gado na SARS-CoV-2 suna iya nuna cewa ba kamar ƙwayar cutar mura ko ƙwayoyin cutar HIV ba, SARS-CoV-2 yana da ƙarancin sauyi wanda yake ba da yiwuwar haɓaka ingantaccen rigakafin duniya.

Browsing by Author "ST Communication"

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