Isah, Murtala, BindawaMuhammad, ZaidLawan, Mohammed, MusaAlkhamis, AbdulrahmanGoni, BabaOakley, SebastianMarshall, KarenHartig, ReneeRaouf, IssaYoshimatsu, TChagas, Andre, MaiaMaina, Mahmoud, Bukar2024-03-142024-03-142023-07-21https://doi.org/10.31730/osf.io/j7at3https://africarxiv.ubuntunet.net/handle/1/468https://doi.org/10.60763/africarxiv/426https://doi.org/10.60763/africarxiv/426https://doi.org/10.60763/africarxiv/426African science has substantial potential, yet it grapples with significant challenges. Here we describe the establishment of the Biomedical Science Research Centre (BioRTC) in Yobe State, Northeast Nigeria, as a case study of a hub fostering on-continent research and describe strategies to surmount some of these barriers. We detail the steps taken to establish BioRTC, emphasising the critical importance of stakeholder engagement, community involvement, resource optimisation, and collaborations. Although we are in the early stages of our journey, our experience can nonetheless serve as a guide to others embarking on similar endeavours in resource-limited settings. We invite the support and collaboration of those who share our vision and believe in our potential.African scienceGenetic DiversityResearch infrastructureResource-limited settingsBiodiversityEthnic Diversity