Berhanu, Mulugeta2024-03-172024-03-172021-07-30https://doi.org/10.31730/osf.io/es9cfhttps://africarxiv.ubuntunet.net/handle/1/731https://doi.org/10.60763/africarxiv/687https://doi.org/10.60763/africarxiv/687https://doi.org/10.60763/africarxiv/687COVID-19 is a devastating viral disease which can be prevented by vaccination. Immunologic adjuvants are key to develop an effective vaccines against infectious diseases in human and non-human primates. Vaccines containing an appropriate adjuvants are crucial for the prevention of various infectious diseases which are the biggest threats to human and animal health. This paper proposes a wide spectrum immunologic adjuvant for vaccine development against COVID-19 which is the current global problem. It has been reported that a wide range of immune cells are involved in the body’s response to SARS CoV2 infection. Therefore, vaccine with a wide-spectrum immunologic adjuvant can be used to provide protection against COVID-19. Lack of adjuvants that can induce the required immune responses is a serious impediment to vaccine development against this devastating virus. The approved adjuvants such as aluminum salts and MF59 exhibit a narrow range of activity. In an attempt to solve this problem, it is crucial to develop new adjuvants which can trigger a wide range of immune cells.Adjuvants for COVID-19vaccinesAluminumsaltsCOVID-19Immunologic adjuvantsMF-59SARS CoV2Vaccine development against COVID-19Vaccine with a wide-spectrum immunologic adjuvant