Welcome to AfricArXiv

This initiative showcases UbuntuNet's commitment to fostering knowledge sharing, collaboration, and accessibility within the African research community. With AfricArxiv, researchers across the continent have a dedicated platform to disseminate their findings, making them accessible to a global audience. By facilitating open access to scholarly work, UbuntuNet Alliance plays a pivotal role in advancing the principles of open science, enhancing research visibility, and driving innovation across Africa.

 

Recent Submissions

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Inhibition Characteristics of Peptide Extracts of Four Medicinal Plants on Activities of Bovine Trypsin
(Elsevier, 2023-07-04) Famutimi, Oladoyin Grace ; Adewale, Isaac Olusanjo; Adegoke,Kehinde Rofiat
Aqueous extract of leaves of Momordica charantia, Hymenocardia acida, Lawsonia inermis and fruit of Xylopia aethiopica have been used in sub Saharan Africa in the management of many viral diseases. Their medicinal properties had been reported to be due to their high antioxidant activities, but limited information is available whether these properties are also due to inhibition or modulation of proteases important in the pathology of viral infections. We report the inhibitory characteristics of peptides extracted from these medicinal plants against bovine trypsin, a serine protease. Extraction of the peptides was done using standard procedure and their inhibitory activities were measured against bovine trypsin. Aqueous extract of M. charantia, H. acida, L. inermis and X. aethiopica contain 5.7 ± 0.5 mg/ml, 1.0 ± 0.2 mg/ml, 1.8 ± 0.1 mg/ml and 28.3 ± 4.1 mg/ml of peptides, respectively. Using Nα-benzoyl-DL-arginine 4-nitroanilide (BAPNA) as trypsin substrate, a Km and Vmax of 0.34 mM and 0.6 μmole/min/mg protein obtained, were altered in the presence of the peptide extracts suggesting the extracts modulate trypsin activity. The inhibition was either competitive, non-competitive or mixed-type of non-competitive inhibition. Inhibition constant (Ki) ranging from 81 to 831±120 μg/ml were obtained using Dixon plot with the peptide extract from M. charantia being the most potent. We concluded that the medicinal and antiviral properties of the extracts could also be due to inhibition or modulation of proteases involved in the pathology of viral infection.
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Large-Scale Synthesis of CISe/ZnS Core-Shell Quantum Dots and Its Effects on the Enzymatic Activity of Recombinant Human Furin (an Activator of SARS-CoV-2 S1/S2 Spike Proteins)
(2023) Vuyelwa Ncapayi; Oladoyin Famutimi; Thabang Calvin Lebepe; Rodney Maluleke; Sam Masha; Nande Mgedle; Sundararajan Parani; Tetsuya Kodama; Isaac Olusanjo Adewale; Oluwatobi Samuel Oluwafemi
We herein report, for the first time, the activity of copper indium selenide/zinc sulphide core-shell quantum dots (CISe/ZnS QDs) as an inhibitor against recombinant human furin, an enzyme that has been implicated in the aetiology of many diseases, including Covid-19. The cell viability of the as-synthesised CISe/ZnS QDs was tested against mouse colon carcinoma cells (C26), while the Furin activity was measured by hydrolysis of peptide substrate Pyr-RTKR-AMC liberating the fluorogenic 7-amino-4-methyl coumarin. The result showed that the as-synthesised stable near-infrared emitting (840 nm) CISe-ZnS QDs is biocompatible against C26 and can inhibit furin with an inhibition constant, Ki, of 15.66 μM. The IC50 was 11.29 ± 0.54 μM, while the enzymatic activity was abolished at about 23 μM of the inhibitor concentration. The results indicate the chemotherapeutic potential of CISe-ZnS QDs as an enzyme inhibitor, which may find application in managing diseases whose pathogenesis involves hyperactivity of furin.
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LA COVID 19 DANS LA VILLE DE TOUBA : DE LA RÉSISTANCE À LA RÉSILIENCE COMMUNAUTAIRE.
(harmattan, Sénégal, 2023-10-05) TOURE, Mamadou Ndong
This article comes from the research project "Transmission of Covid 19 in Senegal: analysis of the socio-spatial dynamics of the factors of propagation in the region of Dakar and the town of Touba", implemented by the LEIDI Laboratory of the Gaston Berger University from 2021 to 2022 (02 years). It analyses the problem of community perception of the COVID-19 pandemic and its evolution in the town of Touba. It takes stock of the factors involved in resistance to and denial of the disease, and of the occupational categories most affected (commerce and transport). The overall aim of the study is to contribute to a better understanding of the community dynamics that prevailed during the Covid 19 pandemic in the city of Touba. Specifically, the aim is to question community players about their perception of the disease, and then the characteristics that explain the spread of the pandemic, particularly in terms of trade and transport. The methodology is based on the overall methodology of the research project mentioned above. The tools of the Active Participatory Research Method were favoured because of their ability to capture socio-economic realities through focus groups, interviews and testimonials, which we combined with a survey of 500 individuals from different socio-professional categories. The main findings are that community-based approaches should be favoured to deal with pandemics and future epidemics. Community transmission is generally linked to the precarious living conditions of a population that is often hard-working and obliged to travel every day in search of daily expenses in places open to the public, notably markets and bus stations.
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The integration of Artificial intelligence (AI) in literature review and its potentials to revolutionize scientific knowledge acquisition
(2024-04-28) Ilegbusi, Paul
This presentation discusses the role of artificial intelligence (AI) in enhancing the literature review process and its potential to transform scientific knowledge acquisition. The presentation highlights the importance of literature review in research and the challenges associated with the traditional manual approach. The presentation emphasizes that integrating AI in literature review can significantly improve efficiency, accuracy, and reduce bias. AI-powered tools can automate various aspects of the literature review process, including search, selection, analysis, and synthesis of relevant literature. The benefits of AI in literature review include increased efficiency, improved coverage of literature, and the ability to identify gaps in knowledge and uncover new research questions. The presentation also provides a comprehensive list of AI tools that can be used in literature review, such as Cramly.ai, Quillbot, GPT-minus 1, ChatGPT, Samwell.ai, and many others. These tools offer functionalities such as rewriting, paraphrasing, summarizing, understanding literature, and extracting key information from articles. The future of AI in literature review is promising, with emerging trends such as deep learning models and knowledge graphs. These trends have the potential to enhance the accuracy and comprehensiveness of literature reviews. In conclusion, the integration of AI in literature review has the potential to revolutionize scientific knowledge acquisition by improving efficiency, accuracy, and coverage of literature. By combining AI with human expertise, researchers can unlock new insights and accelerate scientific progress in various fields.