Browsing by Author "Mohamed, Wael"

Now showing 1 - 8 of 8
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    A Case Study of Multiple Sclerosis (MS)
    (2022-01-02) Mohamed, Wael
    This is a CASE STUDY OF MULTIPLE SCLEROSIS (MS) is designed to be a PBL for teaching for Medical students.
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    A Child with Fits: A Case Report for PBL
    (2021-12-29) Mohamed, Wael
    This is a case report for a child with seizures. It is presented as a PBL for teaching purposes in Medical School for Undergraduate Medical Students
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    AfrAbia Society (AAS): The Secret Ingredient for Advancing AfrAbia Neuroscience Research
    (2022-07-31) Mohamed, Wael
    Africa is marked by a higher frequency of illnesses, trauma, and violence, as well as greater exposure to toxic substances and malnutrition, against a backdrop of far greater genetic variety. All these variables present potential for the neuroscience community in Africa to achieve breakthroughs in fundamental research and develop personalized therapies to boost brain health and well-being throughout the continent. While the high incidence of mental, neurological, and substance-use problems presents unique challenges to the African neuroscience community (Feigin et al., 2017; Feigin et al., 2019), the possibilities are also equally great. For instance, low physician-to-patient ratios expose the average clinician to a high number of patients, hence enhancing possibilities for field-specific competence development. This increased clinical exposure generates topics of study that are directly relevant to the local community, and improves the viability clinical studies, which helps not only the African community, but also the Global North. Recruiting participants for clinical studies on traumatic brain injury, for instance, takes less time in Africa than in Europe. Lastly, there is ample opportunity for clinically oriented neuroscience research to enhance healthcare in Africa, particularly for young people. Specific objectives include the improvement of developmental potential and mental health, as well as the alleviation of mortality and neurological impairment.
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    Arab-Muslims Contributions to Modern Neuroscience: What’s Giving Us Hope?
    (2022-02-21) Mohamed, Wael
    The Arab world encompasses a broader geographical area, covering a wide variety of countries in Asia and Africa. Arab culture is due to much of its development in all the fields of intellectual practice, including in medicine, particularly during the Golden Age of the Arabic Islamic sciences (8th – 13th centuries C.E.). The glorious history of the Arab world allows us to consider the debt of mankind to the golden age of Arab science and assess the contribution of Arab countries to our day's biomedical and neuroscience research.
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    Assessment of Cognitive Functions and Development of Cognitive Based Smartphone Application for Malay Parkinson Disease Patients
    (2021-08-20) Mohamed, Wael
    The current protocol focuses on the development of a computerized model/smartphone application that assesses the cognitive and motor deficits of PD patients at the early stage, thus helping in delaying the progression of disease symptoms and providing more years of healthy life. Dementia Coach App is the proposed name for this new app.
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    Atypical antipsychotic Lumateperone Beyond Schizophrenia: Seeking clarity in a time of Uncertainty
    (2022-01-05) Mohamed, Wael
    Lumateperone (ITI-007) is a serotonin 5HT2A tosylate salt with high affinity for dopamine D2 and D1 receptors and the serotonin transporter. It is unusual in that it controls serotonin, dopamine, and glutamate neurotransmission concurrently, all of which have been implicated in severe mental illness. Consider it a multi-targeted ligand and multifunctional modulator of the serotoninergic system with possible precognitive, antipsychotic, antidepressant, and anxiolytic properties. While lumateperone has been explored as a new agent for schizophrenia therapy, it also provides a unique therapeutic option for a range of other psychiatric and neurological diseases, including behavioural signs of dementia or Alzheimer's disease, sleep problems, and bipolar depression. Additionally, it had a better safety profile than placebo, with no significant extrapyramidal side effects, hyperprolactinemia, or changes in cardiometabolic or endocrine characteristics. Additional study is needed to validate and analyse lumateperone's effectiveness, as well as to identify prospective therapeutic targets. This article gives a comprehensive overview of the most notable results and potential future applications of this chemical in personalised medicine, particularly for neurodegenerative diseases.
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    High-Mobility Group Box 1 (Hmgb1) Protein Evaluation in Mptp-Induced Zebrafish Model of Parkinson’s Disease
    (2021-08-14) Mohamed, Wael; Razali, Khairiah; Othman, Noratikah; Hamza, Mohamed; Doolane, Abdel, Moneem; Kumar, Jaya; Ibrahim, Wisam, Nabeel
    Molecular studies have proven beneficial in understanding the pathophysiology of PD. Besides, the advancing application of zebrafish as a PD model has enabled researchers to conduct molecular studies with more promising outcomes and significance. Current evidence reported on the association of HMGB1 protein with neuroinflammation-induced PD pathogenesis. However, to the extent of our knowledge, the molecular mechanism pertaining to HMGB1 involvement in PD are still elusive. Hence, we propose to conduct a study on HMGB1 protein, to elucidate its role in the pathogenesis of the MPTP-induced zebrafish model of PD. This study will answer the question pertaining to the involvement of HMGB1 in PD development and whether the knockdown of this protein can improve PD symptoms in zebrafish, particularly MPTP-induced motility disorders.
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    The promise of Tele-Dementia: Today’s science and tomorrow’s trial
    (2022-01-12) Mohamed, Wael
    Telemedicine is the term used to describe the use of technology to provide medical care over a distance. Telephone, email, and real-time videoconferencing are the most frequently used telepsychiatry technology. Telemedicine has been used to provide simple and efficient healthcare solutions in the treatment of illness. Despite it is relatively new, mobile health (mHealth) has grown significantly in popularity as a means of assisting persons living with a chronic condition. The current study reviewed existing mobile health dementia applications from different perspectives. These applications could include a variety of strategies and resources to assist the community especially in caring for individuals with Alzheimer's disease.