Publication: Seroconversion of Hepatitis B Vaccine in Young Children in Kwadaso District of Ghana.
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Date
2023-07-15
Journal Title
Journal ISSN
Volume Title
Publisher
Prof. Samuel Sakyi.
Abstract
1.1. Background
Hepatitis B Virus (HBV) infection is an important public health problem that requires high priority efforts towards prevention and control. Active immunization is the single most important and effective preventive measure against HBV infection. As a protective measure, Ghana—after introducing the mass immunization program against hepatitis B infection in children in 2002—continued her Expanded Programme on Immunization (EPI) in 2019. This study evaluated seroconversion (the point in time when the amount of antibody in the blood becomes detectable) and seroprotection (the point in time when the amount of antibody in the blood is enough to confer protection from the antigen that induced it production) status of children under this mass immunization program and measured their antibody levels four years after immunization.
1.2. Materials and Method
220 archived plasma samples of children between the ages of 1–10 years were retrieved from a previous cross-sectional study by researchers from KCCR between 2010 and 2014. Of these, 105 have completed the EPI and were screened for HBsAg. Those found to be HBsAg-seronegative were stratified into three groups according to their age at which the last vaccine was administered. Their anti-HBsAg titer levels were estimated by enzyme linked immunosorbant assay (ELISA).
1.3. Results
Four (1.9%) samples were HBsAg seropositive and were excluded from further analyses. 9 more samples were excluded from analyses because they were insufficient. The anti-HBs titers recorded ranged from 1.021 IU/L to 751.64 IU/L indicating a 100% seroconversion rate. In group one (0–6 months), 87.9% were seroprotected. Group two (2-3yrs) had 78.3% seroprotection and group three (3-5yrs) had 41.7% seroprotection. There was no significant difference between group 1 and 2. However, there was a significant difference between group 1 and 3 (p = 0.0137) and between group 2 and 3 (p = 0.0390) respectively. There was no significant difference between male and female children.
1.4. Conclusion
All the children who received doses of hepatitis B vaccine at 6, 10 and 14 weeks in the immunization program seroconverted, but their levels of protection waned with increasing years. Booster doses are therefore recommended after 5 years.
Description
This study evaluated seroconversion and seroprotection status of children in the Kwadaso District of Ghana, and it's a cross-sectional study.
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Citation
Dassah S, Sakyi SA, Frempong MT, Luuse AT, Ephraim RKD, Anto EO, et al. (2015) Seroconversion of Hepatitis B Vaccine in Young Children in the Kassena Nankana District of Ghana: A Cross-Sectional Study. PLoS ONE 10(12): e0145209. https://doi.org/10.1371/journal.pone.0145209