Legume-Derived Anti-Angiogenic Networks Targeting Renal Cell Carcinoma: Mechanistic Insights into Polyphenol–Saponin–Fiber Bioactive Complexes from Phaseolus vulgaris
Loading...
Files
Date
Authors
Barack Ndenga
Journal Title
Journal ISSN
Volume Title
Publisher
Publisher
Abstract
Renal cell carcinoma (RCC) remains one of the most angiogenesis-dependent solid tumors, characterized by constitutive activation of hypoxia-inducible signaling and resistance to long-term anti-VEGF therapies. Emerging evidence suggests that complex dietary bioactives may exert multi-targeted anti-neoplastic effects beyond single-molecule pharmacology. Here, i propose and mechanistically explore Phaseolus vulgaris (red kidney bean) as a source of integrated anti-angiogenic bioactive complexes composed of polyphenols,saponins, and fermentable fiber-derived metabolites. I demonstrate that these legume-derived compounds act synergistically to suppress RCC proliferation, disrupt tumor-driven angiogenesis, and reprogram metabolic and inflammatory signaling pathways. This work introduces a novel framework positioning legume bioactives as systems-level modulators of renal oncogenesis, opening avenues for complementary nephro-oncological strategies.
Description
Renal cell carcinoma (RCC) is a highly vascularized malignancy driven by dysregulated hypoxia signaling, metabolic reprogramming, and chronic inflammation. Despite advances in anti-angiogenic therapies, long-term clinical efficacy remains limited by adaptive resistance and cumulative toxicity. This work introduces a novel systems-level framework positioning Phaseolus vulgaris (red kidney bean) as a source of integrated legume-derived bioactive complexes capable of modulating multiple oncogenic networks simultaneously.
The manuscript explores the synergistic anti-proliferative and anti-angiogenic roles of polyphenols, saponins, and fiber-derived microbial metabolites, with a specific focus on renal tumor biology. Mechanistic insights highlight the suppression of HIF-driven angiogenesis, inhibition of PI3K/AKT/mTOR signaling, modulation of endothelial function, and activation of AMPK-mediated metabolic control through the gut–kidney–tumor axis
By advancing the concept of Legume-Derived Bioactive Complexes (LDBCs) and applying principles of network pharmacology to nephro-oncology, this work bridges molecular oncology, nutritional biochemistry, and systems medicine. The findings support the repositioning of dietary legumes as complementary, low-toxicity modulators of angiogenesis and tumor progression in renal cell carcinoma, with potential translational relevance for integrative and precision oncology strategies.
Keywords
Citation
DOI
Collections
Endorsement
Review
Supplemented By
Referenced By
Creative Commons license
Except where otherwised noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 United States