Proposal

Permanent URI for this collection

https://africarxiv.ubuntunet.net/handle/1/794

Browse

Browsing Proposal by Issue Date

Filter results by year or month
Now showing 1 - 4 of 4
  • Thumbnail Image
    Item
    Multilingual COVID-19 Information Videos
    (2020-03-26) Bezuidenhout, Louise; McNaughton, Anna; Havemann, Johanna
    We propose to address a lack of CODIV-19 information in local languages with short, consistent messages provided in as many regional/local languages as possible. For that, we need help of researchers and other communicators. This is a proposal to create 2-minute videos in as many languages as possible that present a consistent message about COVID-19, containment strategies and practical health information.
  • Thumbnail Image
    Item
    Anti-proliferative and Chemotherapeutics Effects of Nigerian Honey and Its Polyphenols on Cancer cells
    (2020-10-15) Ahmad, Umar; Buhari, Ibrahim; Umar, Aminu Kura; Usman, Pateh Umar
    Cancer is one of the major deadly diseases affecting humans around the world, Nigeria inclusive. Liver cancer also known as hepatocellular carcinoma (HCC) is the fifth most common cancer in males and the seventh most common cancer in females and the third leading cause of cancer death globally [1]. Limited treatment for high-risk liver cancer and poor prognosis was recorded, in addition to its resistance, recurrence, progression and invasion. Resistance of liver cancer to conventional therapies added to severe side effects prompted the search for a novel therapeutic approach based on natural products such as the Nigerian honey. Honey and its components were documented to have significant anti-cancer activity against many types of cancer including liver cancer in both in vivo and in vitro studies. However, the mechanism of anti-cancer activity of honey as a chemopreventive and therapeutic agent has not been completely elucidated, and to our knowledge, there is no study carried out to investigate the effects of Nigerian honey on cancer cells. It is in view of this that this project aims to pre-clinically evaluate the molecular mechanism of anti-cancer activity of the Nigerian honey on liver cancer cells through the use of molecular techniques. A full understanding of cellular and molecular mechanisms elicit by honey in killing cancer cells may lead to the use of the honey or its polyphenols at clinical level for effective treatment of many types of human cancer in the future.
  • Thumbnail Image
    Item
    Genetic Profiling And In Vitro Characterization Of OTX1 Functional Role On Bladder Cancer Stem Cells
    (2020-10-19) Ahmad, Umar; Yusuf Alhaji, Suleiman; Malami , Sani Abubakar
    Bladder cancer has the highest cost per patient among all cancers due to the high risk of recurrence and the need for life-long routine monitoring as well as therapy. Cancer stem cells (CSCs) are hypothesised to be linked to long-term recurrence risk due to its ability to repopulate the entire tumour population in a small number of cells. In addition, CSC as according to the stem cell model, has the property of self-renewal. Thus, only CSC has sufficient time to accumulate adequate genetic mutations that drive the acquisition of resistance against chemo- and radiation-therapy leading to initiation of recurrence. Recently, OTX1 has been shown to be involved in the differentiation of breast CSCs into differentiated cancer cells. The gene is also reported to be involved in other cancers such as subset of B cells in aggressive non-Hodgkin lymphomas, lung cancer and most recently in bladder cancer. Although the involvement of OTX1 in cancers is demonstrated by limited number of studies, the gene remains to be an interesting candidate for further investigation. We propose that OTX1 may be responsible for the differentiation of CSC and also promote tumour aggressiveness. We plan to establish the expression and localisation patterns of OTX1 gene for Nigerian bladder cancer patients and correlate with clinical characteristics such as stage and grade; risk of recurrence; disease progression and age. To understand the role of OTX1 in bladder cancer stem cells, the gene will be overexpressed/knockdown in non OTX1expressing and OTX1 expressing CSCs, respectively, and the .resulting,. Phenotypic effects will be compared.
  • Thumbnail Image
    Item
    Stabilization of Historical Archives in Mekelle City Municipality. Project Proposal
    (2024-10-01) Asfha, Alula Tesfay; Gebrekristos, Selam; Gebrehiwot, Dawit